The Turkish Journal of Pediatrics 2009 , Vol 51 , Num 5
Graft-Versus-Lymphoma Effect After Reduced Intensity Allogeneic Hematopoietic Stem Cell Transplantation from HLA-Two Loci Mismatched Father in a Patient with Refractory Non-Hodgkin Lymphoma
1Department of Pediatrics, and 2Division of Child Health, Department of Health Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan A 10-year-old female developed a mediastinal mass and was diagnosed as mixed lineage lymphoblastic lymphoma. The tumor was extremely refractory, and she never achieved remission despite intensive therapy using 12 antilymphoma agents and local irradiation. She received reduced-intensity allogeneic peripheral blood stem cell transplantation from her HLA-two loci mismatched father, and achieved complete remission. However, the lymphoma relapsed four months later, and we abruptly discontinued immunosuppressive drugs. Concurrent with the development of grade III graft-versus-host disease, the lymphoma completely disappeared with an increase of activated T-cells in peripheral blood. The clinical course suggested the graft-versus-lymphoma effect against aggressive/refractory lymphoma. Keywords : graft-versus-lymphoma effect, HLA mismatch, child, non-Hodgkin lymphoma.
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