The Turkish Journal of Pediatrics 2009 , Vol 51 , Num 5
The Incidence of Congenital Malformations in Children with Cancer
*1Currently at Department of Pediatrics, Başkent University Faculty of Medicine, Ankara, and Departments of 1Pediatric Oncology, Institute of Oncology, and 2Pediatrics, Dokuz Eylül University Faculty of Medicine, İzmir, Turkey We evaluated the incidence of congenital malformations in 566 children (median age: 8, M:F 1.3) with lymphomas and solid tumors using patient records. In this study, 12.7% of children either had a congenital malformation (7.8%) or a birthmark (4.9%). The incidence of patients with a childhood cancer syndrome was 3% and these cases developed typical tumors. The rate of consanguineous marriages was 12.6%, and family history of cancer was positive in 31.2%. Median age at cancer diagnosis, gender, maternal age, history of stillbirth and missed abortion, consanguinity of parents, and family history of cancer were not significantly different in cases with and without a congenital malformation. The most frequent cancers were central nervous system tumors and lymphomas. No remarkable association between a particular anomaly and a specific cancer type could be shown. The high incidence of congenital anomalies in this study may stimulate future large cohort studies in our country. Keywords : congenital malformation, birthmarks, childhood cancer, childhood cancer syndromes.
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