The Turkish Journal of Pediatrics
2009 , Vol 51 , Num 3
A case of imipramine-associated immune thrombocytopenia
Department of Pediatrics, Karadeniz Technical University Faculty of Medicine, Trabzon, Turkey1,
Drug-induced immune thrombocytopenia (DITP), excluding heparin-induced
thrombocytopenia, is relatively uncommon. It is characterized by drugdependent
antibodies that bind to the platelets and cause their destruction
when the responsible drug is ingested or injected. Imipramine is a tricyclic
antidepressant drug that is one of those used widely for primary enuresis
nocturna, attention deficit hyperactivity disorder, depression, and anxiety
disorder in children and adolescents. Imipramine rarely causes hematological
abnormalities. A five-year-old boy with imipramine-associated antiglobulinpositive
immune thrombocytopenia is reported herein, and we also discuss
the possible pathogenesis of drug-associated thrombocytopenia.
Keywords :
imipramine, immune thrombocytopenia.