The Turkish Journal of Pediatrics 2007 , Vol 49 , Num 2
Fatty liver due to high levels of serum tacrolimus after liver transplantation
1Departments of Pediatric Gastroenterology, Hepatology and Nutrition, Ege University Faculty of Medicine Izmir, Turkey
2Departments of Pathology, Ege University Faculty of Medicine, Izmir, Turkey
3Organ Transplantation and Research Center, Izmir, Turkey
Tümgör G, Arıkan Ç, Nart D, Kılıç M, Aydoğdu S. Fatty liver due to high levels of serum tacrolimus after liver transplantation. Turk J Pediatr 2007; 49: 223-225.

Tacrolimus has been used extensively for immunosuppressive therapy in pediatric liver transplant recipients. However, patients who are exposed to high levels of serum tacrolimus tend to be associated with a higher incidence of significant nephrotoxicity, neurotoxicity, pruritus, alopecia, diabetes and infection.

We herein report a child who developed increased serum transaminase levels and liver steatosis as a result of raised trough blood level of tacrolimus (30 ng/ml for 3 days) in association with rotavirus gastroenteritis. Keywords : Tacrolimus, liver transplantation, fatty liver

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