The Turkish Journal of Pediatrics 2006 , Vol 48 , Num 4
Autoimmune hemolytic anemia as presenting manifestation of primary splenic anaplastic large cell lymphoma
1Departments of Pediatrics, Selçuk University Meram Faculty of Medicine, Konya
2Department of Pathology, Ankara University Faculty of Medicine, Ankara, Turkey
3Departments of Radiology, Selçuk University Meram Faculty of Medicine, Konya
Köksal Y, Çalışkan Ü, Uçar C, Erekul S, İlerisoy-Yakut Z. Autoimmune hemolytic anemia as presenting manifestation of primary splenic anaplastic large cell lymphoma. Turk J Pediatr 2006; 48: 354-356.

Autoimmune hemolytic anemia (AIHA) is an unusual complication of malignancy. We diagnosed primary splenic anaplastic large cell lymphoma (ALCL) in a patient. A seven-year-old boy presented with Coombs testpositive hemolytic anemia. After a course of prednisolone therapy, a complete response for anemia was achieved. Twenty months later, in addition to severe hemolytic anemia, the patient was diagnosed with ALCL after splenectomy and pathologic examination of the sample. The recognition of this clinical picture as a complication of non-Hodgkin’s lymphoma has important implications. The most effective management of AIHA in the setting of cancer is to treat the underlying malignancy. Keywords : autoimmune hemolytic anemia, anaplastic large cell lymphoma, spleen, non-Hodgkin’s lymphoma, childhood

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