The Turkish Journal of Pediatrics 2006 , Vol 48 , Num 2
Peritoneal clearance of biochemical markers of bone turnover in children with end stage renal failure on peritoneal dialysis
1Department of Pediatric Nephrology, Çukurova University Faculty of Medicine, Adana, Turkey
2Department of Pediatric Nephrology, Adana Hospital Başkent University Faculty of Medicine, Adana, Turkey
Turkey
3 Department of Central Laboratory, Adana Hospital Başkent University Faculty of Medicine, Adana, Turkey
Bayazıt AK, Cengiz N, Anarat R, Noyan A, Anarat A. Peritoneal clearance of biochemical markers of bone turnover in children with end stage renal failure on peritoneal dialysis. Turk J Pediatr 2006; 48: 140-142.

Renal osteodystrophy is one of the important complications in children with end stage renal disease. Non-invasive tools for evaluation of bone metabolism have been proposed in recent years. The aim of this study was to investigate the markers of metabolic bone disease and peritoneal clearance of these markers in children treated with continuous ambulatory peritoneal dialysis (CAPD). In this study, serum osteocalcin (OC) levels were found significantly higher in patients (107.98±99.99 ng/ml) than in the healthy control group (41.94±12.94 ng/ml; p<0.05). Mean peritoneal clearance (Clp) of OC was 0.87±0.91 ml/min. There was no correlation between serum OC and Clposteocalcin. There was a positive correlation between serum phosphorus (P) and OC (r=0.394, p=0.031), alkaline phosphatase (ALP) and OC (r=0.520, p=0.003), and parathyroid hormone (PTH) and OC (r=0.441, p=0.017), whereas no correlation was found between OC and calcium (Ca) and OC and magnesium (Mg). There was also a significant correlation between serum ALP and PTH (r=0.714, p=0.0001). A positive correlation was found between serum PTH and Clp of PTH (r=0.471, p=0.009). In conclusion, Clp-osteocalcin is of no interest as a non-invasive marker of metabolic bone disease in children treated with CAPD. But significant correlation between serum OC and PTH, P, and ALP shows that serum OC could be used as a valuable non-invasive biochemical marker of metabolic bone disease. Keywords : osteocalcin, peritoneal clearance, renal osteodystrophy, children

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