The Turkish Journal of Pediatrics 2016 , Vol 58 , Num 1
An unusual case of neuroblastoma: a 17-year-old adolescent presented with bilateral diffuse lung metastasis at initial diagnosis
Çağlar Ödek 1 ,Tanıl Kendirli 1 ,Esra Pekpak 2 ,Ayhan Yaman 1 ,Başak Adaklı-Aksoy 2 ,Handan Dinçaslan 2 ,Nurdan Taçyıldız 2 ,Emel Ünal 2 ,Erdal İnce 1 ,Gülsan Yavuz 2
1 Divisions of Pediatric Critical Care , Ankara University Faculty of Medicine, Ankara, Turkey
2 Divisions of Pediatric Oncology, Department of Pediatrics, Ankara University Faculty of Medicine, Ankara, Turkey
DOI : 10.24953/turkjped.2016.01.012 Neuroblastoma (NB) is the most frequently diagnosed neoplasm during infancy and its incidence declines within the first 3-5 years of life. It can be rarely diagnosed in adolescents and young adults. Adolescents have advanced stage of disease, higher frequency of uncommon metastatic sites such as lungs, and worse outcomes. Herein, we describe an unusual case of NB in a 17-year-old adolescent presented with lung metastasis at diagnosis. The patient was diagnosed with stage IV NB. Thorax high-resolution computed tomography (HRCT) scan revealed irregular septal thickening with ground glass opacity consistent with pulmonary parenchymal metastases. After the first cycle of chemotherapy he developed pulmonary hemorrhage and respiratory distress. He required ventilation support and mechanical ventilation was started. Metastatic nodules were determined on second thorax HRCT. We lost the patient due to septic shock and multiple organ failure 2 months after diagnosis. In conclusion, adolescents with NB have unfavorable prognosis. These patients may have lung metastases at diagnosis. Therefore, detailed chest imaging at initial diagnosis is crucial. Keywords : neuroblastoma, adolescent, lung metastasis, pulmonary hemorrhage
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