The Turkish Journal of Pediatrics 2011 , Vol 53 , Num 1
The Effect Of Gonadotropin-Releasing Hormone Analog Treatment (leuprolide) on Body Fat Distribution in İdiopathic Central Precocious Puberty
1Division of Pediatric Endocrinology, Department of Pediatrics, Gülhane Military Medical Academy, 2Division of Pediatric Endocrinology, Department of Pediatrics, and Departments of 4Biostatistics, 5Pediatrics and 6Radiodiagnostics, Ankara University Faculty of Medicine, Ankara, and 3Division of Pediatric Endocrinology, Department of Pediatrics, İnönü University Faculty of Medicine, Malatya, Turkey Taşcılar ME, Bilir P, Akıncı A, Köse K, Akçora D, İnceoğlu D, Fitöz SÖ. The effect of gonadotropin-releasing hormone analog treatment (leuprolide) on body fat distribution in idiopathic central precocious puberty. Turk J Pediatr 2011; 53: 27-33.

Gonadotropin-releasing hormone analog (GnRHa) therapy is used in idiopathic central precocious puberty (ICPP) worldwide. It has also been shown that during this therapy, body mass index (BMI) increases slightly as a side effect. We investigated the side effects of GnRHa treatment in ICPP on body composition and insulin resistance (IR). Twenty girls (7.55±1.02 y) with ICPP were treated with GnRHa (leuprolide) for an average of 20.83±4.8 months. Bioelectrical Impedance Analysis (BIA) was used to measure the body's fat balance. Nine patients out of 20 (45%) had significant gain weight. We showed a significant elevation in trunk fat mass compare to baseline values (p<0.01). These nine patients had high homeostasis model assessment (HOMA)-IR and low glucose/insulin (G/I) index. This study showed a slight increase in BMI, moderate increase in total body fat, and exaggerated elevation in trunk fat mass and IR in GnRHa-treated ICPP children. Keywords : leuprolide, precocious puberty, obesity, body fat composition, body mass index, hyperinsulinism.

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