The Turkish Journal of Pediatrics
2010 , Vol 52 , Num 2
Acral Erythema with Bullous Formation: A Side Effect of Chemotherapy in a Child with Acute Lymphoblastic Leukemia
Department of Pediatric Hematology, Hacettepe University Faculty of Medicine, Ankara, Turkey
Chemotherapy-induced acral erythema (CIAE) with bullous formation is an
uncommon complication in children. We describe herein a child who developed
CIAE with bullous formation following high-dose methotrexate and cytarabine
for relapsed acute lymphoblastic leukemia. The rash completely resolved
within two weeks of the appearance without any specific treatment. CIAE
may develop in children with hematological malignancies as a complication
of pediatric chemotherapeutic regimens, and pediatricians should be aware
of this phenomenon despite its rarity.
Keywords :
acute lymphoblastic leukemia, acral erythema, child.