The Turkish Journal of Pediatrics 2021 , Vol 63 , Num 3
Using lactate dehydrogenase to predict the severity of respiratory distress in term newborn infants with no perinatal asphyxia
Miran Lee 1 ,Narae Lee 1 ,Mi Hye Bae 2 ,Young Mi Han 1 ,Kyung Hee Park 2 ,Shin Yun Byun 1 ,Choongrak Kim 3
1 Department of Pediatrics, Pusan National University Children’s Hospital, Pusan National University School of Medicine, Yangsan, South Korea
2 Department of Pediatrics, Pusan National University Hospital, Pusan National University School of Medicine, Busan, South Korea
3 Department of Statistics, Pusan National University, Busan, South Korea
DOI : 10.24953/turkjped.2021.03.006 Background. We aimed to establish whether knowledge of lactate dehydrogenase (LDH) levels on day 1, as well as the change in these levels in the first three days, could be of clinical benefit in the diagnosis and/or prediction of severity of respiratory distress syndrome (RDS) and transient tachypnea of the newborn (TTN).

Methods. A retrospective study was conducted on 275 term infants (35 with RDS and 240 with TTN) admitted to the neonatal intensive care unit from January 2014 to June 2019. LDH levels were measured on admission and after three days.

Results. Both RDS and TTN groups had elevated LDH levels during admission. LDH levels were significantly higher in the RDS group than in the TTN group on both days. LDH levels in both groups significantly correlated with both the duration of respiratory support required, as well as the number of hospital days. We used these outcomes as a measure of severity of these conditions.

Conclusions. In patients with respiratory distress, it may not be clinically useful to use LDH levels on day 1 to differentiate between RDS and TTN, despite the statistically significant differences, because of the overlapping values. However, LDH levels on day 1 and day 3 may predict the degree and duration of the required respiratory support for both RDS and TTN groups. Keywords : lactate dehydrogenase, transient tachypnea of the newborn, neonate, hyaline membrane disease

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