The Turkish Journal of Pediatrics 2019 , Vol 61 , Num 5
Cardiometabolic risk factors in Turkish children with hepatosteatosis
Ahmet Aslan 1 ,Servet Erdemli 1 ,Gülçin Durukan Günaydın 1 ,Mine Aslan 1 ,Ramazan Ömer Yazar 2 ,Adnan Kabaalioğlu 1 ,Mehmet Ali Ağırbaşlı 3
1 Departments of Radiology, Istanbul Medeniyet University, Göztepe Training and Research Hospital, Kadıköy, Istanbul, Turkey
2 School of Medicine, Istanbul Medeniyet University, Kadıköy, Istanbul, Turkey
3 Departments of Cardiology, Istanbul Medeniyet University, Göztepe Training and Research Hospital, Kadıköy, Istanbul, Turkey
DOI : 10.24953/turkjped.2019.05.010 Aslan A, Erdemli S, Durukan Günaydın G, Aslan M, Yazar RÖ, Kabaalioğlu A, Ağırbaşlı MA. Cardiometabolic risk factors in Turkish children with hepatosteatosis. Turk J Pediatr 2019; 61: 714-722.

We aimed to investigate the prevalence of cardiometabolic (CM) risk factors (impaired fasting glucose (>100 mg/dL), high blood pressure, overweight or obesity, high serum triglycerides (TG) and low serum high-density lipoprotein cholesterol levels) in children with hepatosteatosis detected by abdominal ultrasound. Children whom ultrasound examination revealed hepatic steatosis were included in the study. Medical records, anthropometric and biochemical parameters were reviewed for the presence of the CM risk factors. Presence of ≥3 risk factors was defined as metabolic syndrome (MS).

One hundred and forty-eight children and adolescents (67 boys, 81girls, and mean age 12.1±2.7 years) with hepatosteatosis were included. Sonographic hepatosteatosis grades of 1, 2 and 3 were observed in 111 (75%), 33 (22.3%), and 4 (2.7%) subjects, respectively. MS was observed in 36 patients (24.3%). The number of CM risk factors and degree of hepatic steatosis were correlated (r=0.183, p=0.026). Serum TG levels in girls and age in boys were significantly associated with the presence of medium to severe hepatosteatosis (grades 2 or 3) (R2=.342, =.040 and R2=.538, p=.001, respectively). CM risk factors and MS are common in children with hepatosteatosis. The presence and grade of hepatosteatosis on ultrasound can be used as surrogate markers of MS and CM risk in children. Keywords : pediatric, ultrasonography, hepatosteatosis, cardiometabolic risk factors

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