The Turkish Journal of Pediatrics 2018 , Vol 60 , Num 5
Asymptomatic intracranial hemorrhage in a newborn with congenital factor VII deficiency and successful treatment with recombinant activated factor VII
Zeynep İnce 1 ,Özgül Bulut 1 ,Melike Tuğrul-Aksakal 1 ,Ayşegül Ünüvar 2 ,Ömer Devecioğlu 2 ,Asuman Çoban 1
1 Divisions of Neonatology, İstanbul University İstanbul Faculty of Medicine, İstanbul, Turkey
2 Hematology and Oncology, Department of Pediatrics, İstanbul University İstanbul Faculty of Medicine, İstanbul, Turkey
DOI : 10.24953/turkjped.2018.05.014 İnce Z, Bulut Ö, Tuğrul-Aksakal M, Ünüvar A, Devecioğlu Ö, Çoban A. Asymptomatic intracranial hemorrhage in a newborn with congenital factor VII deficiency and successful treatment with recombinant activated factor VII. Turk J Pediatr 2018; 60: 562-565.

Intracranial hemorrhage is considered the most common cause of death in newborns with congenital factor VII (FVII) deficiency. Recombinant activated FVII (rFVIIa) provides specific replacement therapy, however there is limited experience with its neonatal use. We describe our experience about the treatment of intracranial hemorrhage in a newborn with congenital FVII deficiency and emphasize the importance of imaging in asymptomatic patients. She presented with ecchymoses on her skin, no other pathological clinical signs, prolonged PT, normal PTT and FVII activity of 2%. Intracranial hemorrhage was diagnosed while screening for internal bleedings. Treatment with rFVIIa resulted in stabilization and regression of the hematoma. Keywords : factor VII deficiency, intracranial hemorrhage, newborn, recombinant activated factor VII

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