The Turkish Journal of Pediatrics 2012 , Vol 54 , Num 1
Seroprevalence of Bordetella pertussis Immunoglobulin G Antibodies among Children in Samsun, Turkey
2Division of Pediatric Infectious Diseases, 1Department of Pediatrics and 3Department of Microbiology and Infectious Diseases, Ondokuz Mayıs University Faculty of Medicine, Samsun, Turkey Özkal A, Şensoy G, Acuner Ç, Belet N, Güney AK. Seroprevalence of Bordetella pertussis immunoglobulin G antibodies among children in Samsun, Turkey. Turk J Pediatr 2012; 54: 15-19.

In this study, we aimed to investigate anti-pertussis immunoglobulin (Ig) G antibodies in the serum of children in our region vaccinated against pertussis with four doses. Between August 2008-2009, antibody levels to Bordetella pertussis (B. pertussis) antigens were studied in 385 serum samples from healthy children aged 1.5-18 years (y) vaccinated against pertussis in Samsun, Turkey. The study population was divided into six groups according to ages: 1.5-3 y; 4-5 y; 6-8 y; 10-12 y; 13-15 y; and 16-18 y. IgG antibodies to B. pertussis antigens were measured with a commercial ELISA kit. Mean age of the children was 9.6 ± 5.3 y. Anti-pertussis IgG titers were positive in 48.3% of the cases. The lowest positivity rate was determined in the 4-5 y age group (28.1%) and the highest rate in the 16-18 y age group (64.2%). Geometric mean titer of anti-pertussis antibodies was 39.2 IU/ml, and again the lowest value was obtained in the 4-5 y age group (23.3 IU/ml) and the highest in the 16-18 y age group (51.4 IU/ml). The antibody levels to B. pertussis antigens significantly decrease 4-6 years after vaccination and again increase in school children, possibly due to natural infection. Keywords : vaccination, booster, pertussis.

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