The Turkish Journal of Pediatrics 2022 , Vol 64 , Num 1
Bladder granulocytic sarcoma in a child: case report and literature review
Rumeysa Tuna 1 ,Serap Karaman 1 ,Tayfun Oktar 2 ,Sema Anak 1 ,Öner Doğan 3 ,Ayşegül Ünüvar 1 ,Deniz Tuğcu 1 ,Zuhal Bayramoğlu 4 ,Suar Çakı Kılıç 5 ,Ayça İribaş Çelik 6 ,Zeynep Karakaş 1
1 Departments of Pediatric Hematology and Oncology, İstanbul University Faculty of Medicine, İstanbul, Turkey
2 Departments of Urology, İstanbul University Faculty of Medicine, İstanbul, Turkey
3 Departments of Pathology, İstanbul University Faculty of Medicine, İstanbul, Turkey
4 Departments of Radiology, İstanbul University Faculty of Medicine, İstanbul, Turkey
5 Department of Pediatric Hematology-Oncology, University of Health Sciences İstanbul Umraniye Training and Research Hospital, İstanbul
6 Department of Radiation Oncology, İstanbul University Oncology Institute, İstanbul, Turkey
DOI : 10.24953/turkjped.2020.275 Background. Granulocytic sarcoma (GS) is an extramedullary solid tumor composed of immature myeloid cells. GS has been associated with acute myeloid leukemia (AML), myelodysplastic syndromes or myeloproliferative diseases. Although GS can affect various tissues of the human body, it has rarely been reported in other soft tissues such as the breast, gastrointestinal, respiratory and genitourinary tracts. We report a pediatric case diagnosed with granulocytic sarcoma of the bladder and concomitant AML.

Case. A twelve-year-old previously healthy girl was admitted to the pediatric urology clinic with a ten-day history of hematuria and pollakiuria. Laboratory examinations revealed anemia, thrombocytopenia and neutrophilic leukocytosis. Bone marrow aspiration results were consistent with acute myeloid leukemia -FAB subtype M2-. Abdominal magnetic resonance imaging (MRI) showed an irregularly bounded 12 cm mass on the right side of the bladder. Transurethral resection (TUR) pathology was consistent with granulocytic sarcoma. After a multimodal treatment approach, complete remission was achieved.

Conclusions. Malignant bladder masses are rare causes of macroscopic hematuria in childhood. The diagnostic spectrum is wide, ranging from rhabdomyosarcoma to leukemia involvement. The bladder is a rare site of extramedullary involvement in pediatric patients with AML. Multimodal treatment should be considered on a per-patient basis. Keywords : acute myeloid leukemia, children, granulocytic sarcoma, bladder, treatment

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