The Turkish Journal of Pediatrics 2008 , Vol 50 , Num 5
Adult height in Turkish patients with Turner syndrome without growth hormone treatment
1Department of Pediatrics, Marmara University Faculty of Medicine, İstanbul, Turkey
2Departments of Genetics, İstanbul University Cerrahpaşa Faculty of Medicine, İstanbul, Turkey
5 Departments of Pediatrics, İstanbul University Cerrahpaşa Faculty of Medicine, İstanbul, Turkey
4Department of Pediatrics, İstanbul University İstanbul Faculty of Medicine, İstanbul, Turkey
3Division of Pediatric Endocrinology, Department of Pediatrics, Şişli Etfal State Hospital, İstanbul, Turkey
6Goztepe State Hospital, İstanbul, Turkey
7Tepecik State Hospital, İstanbul, Turkey
8Department of Pediatrics, Ege University Faculty of Medicine, İzmir, Turkey
9Departments of Pediatrics, Atatürk University Faculty of Medicine, Erzurum, Turkey
10Department of Medical Genetics, Cumhuriyet University Faculty of Medicine, Sivas, Turkey
11Department of Pediatrics, Selçuk University Faculty of Medicine, Konya, Turkey
12Department of Endocrinology, Ankara University Faculty of Medicine, Ankara, Turkey
SUMMARY: Bereket A, Turan S, Elçioğlu N, Hacıhanefioğlu S, Memioğlu N, Baş F, Bundak R, Darendeliler F, Günöz H, Saka N, Ercan O, Arslanoğlu İ, İşguven P, Yıldız M, Can Ş, Özerkan E, Çoker M, Darcan Ş, Özkan B, Orbak Z, Öztaş S, Palandüz Ş, Sezgin İ, Atabek E, Erkul İ, Erdoğan G. Adult height in Turkish patients with Turner syndrome without growth hormone treatment. Turk J Pediatr 2008; 50: 415-417.

Spontaneous adult height (AH) in Turner syndrome (TS) varies among populations. Population-specific AH data is essential to assess the efficacy of growth-promoting therapies in TS. A multicenter study was performed to establish AH of nongrowth hormone (GH)-treated Turkish patients with TS.

One hundred ten patients with TS (diagnosed by karyotype) who reached AH (no growth in the previous year, or bone age >15 years) without receiving GH treatment were included in the study.

The average AH was found to be 141.6±7.0 cm at the age of 22.9±6.2 years, which is 18.4 cm below the population average and 16.4 cm below the patients' mid-parental heights. Bone age at start of estrogen replacement was 12.3±1.3 year. Karyotype distribution of the patients was 45X (43%), 45X/46XX (16%), 45X/46Xi (12%), 45XiXq (10%) and others (19%). When the patients were evaluated according to their karyotype as 45X and non-45X, no significant difference in AH was observed (142.4±6.9 cm vs 140.9±7.1 cm, respectively).

Adult height of non-GH-treated Turkish TS patients obtained in this study was comparable to that of other Mediterranean populations, but shorter than that of Northern European patients. Karyotype does not seem to affect AH in TS. Keywords : Turner syndrome, final height, adult height, karyotype, growth, growth hormone.

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