The Turkish Journal of Pediatrics 2008 , Vol 50 , Num 4
Severe sepsis in a premature neonate: protein C replacement therapy
Division of Neonatal Intensive Care, Department of Pediatrics, Catholic University of Sacred Heart, Rome, Italy De Carolis MP, Polimeni V, Papacci P, Lacerenza S, Romagnoli C. Severe sepsis in a premature neonate: protein C replacement therapy. Turk J Pediatr 2008; 50: 405-408.

Treatment with activated protein C has been shown to reduce mortality in adult patients with severe sepsis but also to increase risk of bleeding. In patients with predisposition to bleeding, as in preterm infants, the inactivated form of protein C could serve as a safe therapeutic option.

We report the case of a preterm neonate who developed severe sepsis on the 28th day of life, who was successfully treated with the inactivated form of protein C for a period of 96 hours. Keywords : protein C, neonatal sepsis

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