The Turkish Journal of Pediatrics 2006 , Vol 48 , Num 3
Tracing immature myelin in acute disseminated encephalomyelitis
1Departments of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey
2Departments of Radiology, Hacettepe University Faculty of Medicine, Ankara, Turkey
3Hacettepe University Faculty of Physics Engineering, Ankara, Turkey
4Dr. Sami Ulus Children’s Hospital, Ankara, Turkey
5Department of Pediatric Neurology, Çukurova University Faculty of Medicine, Adana, Turkey
6Department of Pediatric Neurology, Karadeniz Technical University Faculty of Medicine, Trabzon, Turkey
7Departments of Biostatistics, Hacettepe University Faculty of Medicine, Ankara, Turkey
Anlar B, Karlı-Oğuz K, Yurtyapan OY, Şenbil N, Hergüner Ö, Altunbaşak Ş, Sönmez FM, Özdemir-Geyik P. Tracing immature myelin in acute disseminated encephalomyelitis. Turk J Pediatr 2006; 48: 197-201.

Inherent abnormalities of myelin have been suggested in the pathogenesis of multiple sclerosis (MS). We investigated myelin in acute disseminated encephalomyelitis (ADEM) patients by magnetic resonance spectroscopy (MRS) and cerebrospinal fluid (CSF) analysis for citrulline, a marker of immature myelin. A citrulline peak was observed in the normal appearing white matter of 7/15 patients and of 1/10 age-matched neurological controls (p=0.08). CSF citrulline was elevated in 4/6 patients. Alterations in the composition of myelin might predispose to or follow acute inflammatory disorders of the central nervous system. Keywords : myelin, acute disseminated encephalomyelitis, citrulline, magnetic resonance spectroscopy

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