The Turkish Journal of Pediatrics
2005 , Vol 47 , Num 4
Use of alendronate in the treatment of vitamin D intoxication in infants
Division of Pediatric Endocrinology, Department of Pediatrics, Kocaeli University Faculty of Medicine, Kocaeli, Turkey
Hatun Ş, Çizmecioğlu F. Use of alendronate in the treatment of vitamin D intoxication in infants. Turk J Pediatr 2005; 47: 373-375.Vitamin D intoxication remains a challenging problem due to lack of an efficient treatment. Bisphosphonates, inhibitors of osteoclast-mediated bone resorption, however, have been proposed as a safe and effective alternative in the treatment of vitamin D intoxication. We present here two infants with vitamin D intoxication who were successfully treated with alendronate. We propose that oral alendronate is an alternative to intravenous bisphosphonates in the treatment of vitamin D intoxication in infancy.
Keywords : bisphosphonates, vitamin D intoxication, infancy