The Turkish Journal of Pediatrics 2017 , Vol 59 , Num 4
The role of plasmapheresis in organophosphate poisoning: Case reports of three pediatric patients
Ufuk Yükselmiş 1 ,Mustafa Özçetin 2 ,Yakup Çağ 1 ,Dinçer Yıldızdaş 3 ,Hayri Levent Yılmaz 4
1 Department of Pediatrics, Dr. Lutfi Kirdar Kartal Training and Research Hospital, University of Health Sciences, İstanbul
2 Department of Pediatrics, Istanbul University Istanbul Faculty of Medicine, İstanbul
3 Departments of Pediatric Intensive Care, Cukurova University Faculty of Medicine, Adana, Turkey
4 Departments of Pediatric Emergency, Cukurova University Faculty of Medicine, Adana, Turkey
DOI : 10.24953/turkjped.2017.04.020 Yükselmiş U, Özçetin M, Çağ Y, Yıldızdaş D, Yılmaz HL. The role of plasmapheresis in organophosphate poisoning: Case reports of three pediatric patients. Turk J Pediatr 2017; 59: 491-496.

The aim of the study was to assess the impact of plasmapheresis treatment in the management of three pediatric patients with organophosphate poisoning who did not respond to standard treatment. The treatment of signs and symptoms, and supportive treatment has been evaluated in this paper.

Patients were initially given atropine infusion and 0.05 mg/kg atropine with five-minute intervals. Despite pralidoxime loading and three consecutively infusions clinical symptoms did not respond to the treatment and plasma pseudocholinesterase levels did not decrease. At this point, plasmapheresis was used on three consecutive days. Accordingly, the clinical signs improved and mechanical ventilation was no longer necessary. Patients were discharged on the sixteenth day after their admission to the hospital.

Plasmapheresis may be an option for the patients who do not respond to atropine and pralidoxime treatment in organophosphate poisoning. Keywords : organophosphate, poisoning, plasmapheresis

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