The Turkish Journal of Pediatrics 2015 , Vol 57 , Num 6
Celiac disease in patients with Williams-Beuren syndrome
Ercan Mıhçı 1 ,Banu Güzel Nur 1 ,Sibel Berker-Karaüzüm 2 ,Aygen Yılmaz 3 ,Reha Artan 3
1 Divisions of Pediatric Genetics, Akdeniz University Faculty of Medicine, Antalya, Turkey
2 Department of Medical Biology and Genetics, Akdeniz University Faculty of Medicine, Antalya, Turkey
3 Pediatric Gastroenterology, Department of Pediatrics Akdeniz University Faculty of Medicine, Antalya, Turkey
Celiac disease is an autoimmune, gastrointestinal disorder characterized by intolerance to the dietary grain protein gluten. An increased prevalence of celiac disease has been reported in Down syndrome and Turner syndrome, but there has been only few previous reports with respect to the association of celiac disease in Williams-Beuren syndrome. The aim of this study was to evaluate the frequency of celiac disease in our 24 Williams-Beuren syndrome patients. Gastrointestinal problems and celiac disease symptoms of patients were noted. All patients were analyzed by the titer of tissue transglutaminases IgA and IgG. HLA genotyping and intestinal biopsy was performed to the patients with positive serology. We also performed gluten free diet in the presence of compatible symptoms, serology, HLA genotyping and intestinal biopsy. In our study, two patients had positive tTG antibodies, but only one had positive biopsy finding for celiac disease. The frequency of celiac disease in patients with Williams–Beuren syndrome was estimated as 1/24 (4.1%). Though the number of participants in this study was limited, the results show that the frequency of celiac disease is higher in Williams-Beuren syndrome compared to the general population. We suggest that a high suspicion and testing for celiac disease should be recommended at certain intervals in all cases with Williams-Beuren syndrome to detect the cause of growth retardation and gastrointestinal problems. Keywords : Williams-Beuren syndrome, celiac disease, tissue transglutaminase antibodies, intestinal biopsy, gluten-free diet
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