The Turkish Journal of Pediatrics 2015 , Vol 57 , Num 3
TSEN54 Gene-Related Pontocerebellar Hypoplasia Type 2 Presenting with Exaggerated Startle Response: Report of Two Cases in a Family
1Division of Child Neurology, Department of Pediatrics, Kocaeli University Faculty of Medicine, Kocaeli, Turkey, and 2Laboratory for Pediatric Brain Diseases, The Rockefeller University, New York, U.S.A.
E-mail: hulyamaras@gmail.com
The pontocerebellar hypoplasias (PCHs) are a heterogeneous group of autosomal recessive disorders characterized by hypoplasia of the ventral pons and cerebellum, with variable cerebral involvement and severe psychomotor retardation. Eight different subtypes (PCH1-8) have been reported up to now. PCH2 is the most common type, generally caused by homozygous mutations in the TSEN54 gene and characterized by cerebellar hypoplasia that affects the hemispheres more severely than the vermis, progressive cerebral atrophy, microcephaly, dyskinesia, seizures and death in early childhood. We present two cousins with PCH2. Both patients presented with exaggerated startle response in the newborn period. Here we discuss the clinical and neuroradiological findings of PCH2, and its differentiation from familial startle disease or hereditary hyperekplexia. Keywords : pontocerebellar hypoplasia, TSEN54 gene, hyperekplexia, startle disease.
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