The Turkish Journal of Pediatrics
2015 , Vol 57 , Num 1
Idiopathic Central Diabetes Insipidus Presenting in a Very Low Birth Weight Infant Successfully Managed with Lyophilized Sublingual Desmopressin
Departments of Neonatology, 1Adana Gynecology and Obstetric and Children’s Hospital, 2Başkent University Faculty of
Medicine, and 4Adana Acıbadem Hospital, and 3Department of Pediatrics, Adana Numune Training and Research Hospital,
Adana, Turkey. E-mail: dhanta@gmail.com
Neonatal central diabetes insipidus (DI) is an extremely rare disorder that
can cause severe morbidity and mortality. We have reported a very low birth
weight infant with idiopathic central DI presenting in the first month of life
who was successfully treated with sublingual desmopressin therapy. In this
report, we emphasize that central DI should be kept in mind in an infant
with unexplained hypernatremia and polyuria. Timely diagnosis and treatment
with lyophilized desmopressin may prevent severe morbidity and mortality.
Keywords :
central diabetes insipidus, premature infant, desmopressin therapy,
hypernatremia, polyuria.