The Turkish Journal of Pediatrics 2012 , Vol 54 , Num 2
Ganglioneuroma in a Child with Hereditary Spherocytosis
Divisions of 1Pediatric Oncology, 3Pediatric Pathology, and 5Pediatric Hematology, 2Department of Pediatrics, and 4Department of Pediatric Surgery, Ankara Children’s Hematology Oncology Training and Research Hospital, Ankara, Turkey Hereditary spherocytosis (HS) is the most frequent cause of congenital hemolytic anemia. Extramedullary hematopoiesis (EMH) mimicking a mass may develop in the lymph nodes, kidneys, pleura, mediastinum, adrenal gland, and in particular the spleen and liver. Other than EMH, B-cell lymphoma, acute lymphoblastic leukemia, and pancreatic schwannoma cases were reported in patients with HS. We present a 13-year-old female patient with HS and ganglioneuroma in the adrenal gland. This association is probably coincidental; however, with increasing cancer cases in HS and the genetic studies being made, this association will be clarified. Keywords : hereditary spherocytosis, child, ganglioneuroma, adrenal gland, cytogenetics, extramedullary hematopoiesis.
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