The Turkish Journal of Pediatrics 2002 , Vol 44 , Num 4
Childhood onset of narcolepsy-cataplexy syndrome in Turkey: clinical and genetic study
Department of Neurology, İstanbul University Cerrahpaşa Faculty of Medicine, Istanbul, Turkey Pelin Z, Bozluolcay M, Kaynak D, Kaynak H. Childhood onset of narcolepsy-cataplexy syndrome in Turkey: clinical and genetic study. Turk J Pediatr 2002; 44: 321-325.

Narcolepsy is a disabling sleep disorder characterized by excessive daytime sleepiness and abnormal manifestations of rapid eye movement (REM) sleep including cataplexy, sleep paralysis and hypnagogic hallucinations. It is known to be complex disorder in which both genetic predisposition and environmental factors play a role. In humans, susceptibility to narcolepsy is tightly associated with a specific HLA allele, DQB1*0602. In this report, we took advantage of the ongoing genetic study in Turkish narcoleptic patients to document clinical and genetic data of eight patients whose onset of symptoms were in the childhood period. Keywords : narcolepsy-cataplexy syndrome, HLA DQB1 *0602, excessive daytime sleepiness

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