The Turkish Journal of Pediatrics 2017 , Vol 59 , Num 1
Predictors of methotrexate response in Turkish children with oligoarticular and polyarticular juvenile idiopathic arthritis
Ezgi Deniz Batu 1 ,Hafize Emine Sönmez 1 ,Bora Gülhan 2 ,Zehra Serap Arıcı 1 ,Rezan Topaloğlu 2 ,Yelda Bilginer 1
1 Division of Rheumatology, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey
2 Division of Nephrology, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey
DOI : 10.24953/turkjped.2017.01.002 Batu ED, Sönmez HE, Gülhan B, Arıcı ZS, Topaloğlu R, Bilginer Y. Predictors of methotrexate response in Turkish children with oligoarticular and polyarticular juvenile idiopathic arthritis. Turk J Pediatr 2017; 59: 6-12.

Methotrexate (MTX) is the most commonly used disease modifying anti-rheumatic drug in juvenile idiopathic arthritis (JIA). We aimed to define predictor factors for response to MTX in Turkish children with oligo- and polyarticular JIA. We reviewed the medical files of 59 oligo- and 57 polyarticular JIA patients seen in the clinic between May 2008 and May 2013 and who received MTX for ≥6 months. MTX responders were defined as having no/low disease activity according to juvenile arthritis disease activity score 71 (JADAS71) at 6 months after MTX initiation. Median age at JIA diagnosis/MTX initiation was 70/78 months. Involvement of the small or upper extremity joints at disease diagnosis and MTX initiation was more frequent; antinuclear antibody (ANA) positivity was less frequent; acute phase reactants, JADAS71 at MTX initiation, and the frequency of polyarticular subtype were higher in MTX non-responders. In multiple logistic regression, oligoarticular JIA subtype and ANA positivity were independent predictors of MTX response. Keywords : juvenile idiopathic arthritis, methotrexate, oligoarticular, polyarticular, treatment

Copyright © 2016 turkishjournalpediatrics.org