The Turkish Journal of Pediatrics
2016 , Vol 58 , Num 6
Response to cimetidine in a 1-year-old child with PFAPA syndrome
1 Cho-ritsu Tara Hospital, Tara, Saga, Japan2 Department of Paediatrics, Ureshino Medical Center, Ureshino, Saga, Japan DOI : 10.24953/turkjped.2016.06.020 Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome is characterized by periodic febrile attacks recurring regularly every 2 to 8 weeks. Although tonsillectomy is offered as an effective treatment, the effectiveness of cimetidine treatment is still controversial. In this article, we describe two cases. A 1-year-old girl with PFAPA syndrome received cimetidine treatment and febrile attacks were reduced. Tonsillectomy was successfully performed on a 6-year-old boy with PFAPA syndrome. We suggest that the use of cimetidine may reduce febrile attacks of PFAPA syndrome until an age that is safer for tonsillectomy. Keywords : cimetidine, tonsillectomy, PFAPA syndrome, febrile attacks